Polymer-free Drug-Coated Coronary Stents in Patients at High Bleeding Risk.
Identifieur interne : 002A03 ( Main/Exploration ); précédent : 002A02; suivant : 002A04Polymer-free Drug-Coated Coronary Stents in Patients at High Bleeding Risk.
Auteurs : Philip Urban ; Ian T. Meredith ; Alexandre Abizaid ; Stuart J. Pocock ; Didier Carrié ; Christoph Naber ; Janusz Lipiecki ; Gert Richardt ; Andres I Iguez ; Philippe Brunel ; Mariano Valdes-Chavarri ; Philippe Garot ; Suneel Talwar ; Jacques Berland ; Mohamed Abdellaoui ; Franz Eberli ; Keith Oldroyd ; Robaayah Zambahari ; John Gregson ; Samantha Greene ; Hans-Peter Stoll ; Marie-Claude MoriceSource :
- The New England journal of medicine [ 1533-4406 ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Antiagrégants plaquettaires (usage thérapeutique), Association thérapeutique, Conception de prothèse, Endoprothèses (effets indésirables), Endoprothèses à élution de substances (effets indésirables), Estimation de Kaplan-Meier, Femelle, Humains, Immunosuppresseurs (administration et posologie), Intervention coronarienne percutanée, Maladie des artères coronaires (), Maladie des artères coronaires (traitement médicamenteux), Mâle, Méthode en double aveugle, Polymères, Sirolimus (administration et posologie), Sirolimus (analogues et dérivés), Sujet âgé.
- MESH :
- administration et posologie : Immunosuppresseurs, Sirolimus.
- analogues et dérivés : Sirolimus.
- effets indésirables : Endoprothèses, Endoprothèses à élution de substances.
- traitement médicamenteux : Maladie des artères coronaires.
- usage thérapeutique : Antiagrégants plaquettaires.
- Adulte d'âge moyen, Association thérapeutique, Conception de prothèse, Estimation de Kaplan-Meier, Femelle, Humains, Intervention coronarienne percutanée, Maladie des artères coronaires, Mâle, Méthode en double aveugle, Polymères, Sujet âgé.
English descriptors
- KwdEn :
- Aged, Combined Modality Therapy, Coronary Artery Disease (drug therapy), Coronary Artery Disease (therapy), Double-Blind Method, Drug-Eluting Stents (adverse effects), Female, Humans, Immunosuppressive Agents (administration & dosage), Kaplan-Meier Estimate, Male, Middle Aged, Percutaneous Coronary Intervention, Platelet Aggregation Inhibitors (therapeutic use), Polymers, Prosthesis Design, Sirolimus (administration & dosage), Sirolimus (analogs & derivatives), Stents (adverse effects).
- MESH :
- chemical , administration & dosage : Immunosuppressive Agents, Sirolimus.
- adverse effects : Drug-Eluting Stents, Stents.
- chemical , analogs & derivatives : Sirolimus.
- drug therapy : Coronary Artery Disease.
- chemical , therapeutic use : Platelet Aggregation Inhibitors.
- therapy : Coronary Artery Disease.
- Aged, Combined Modality Therapy, Double-Blind Method, Female, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Percutaneous Coronary Intervention, Polymers, Prosthesis Design.
Abstract
Patients at high risk for bleeding who undergo percutaneous coronary intervention (PCI) often receive bare-metal stents followed by 1 month of dual antiplatelet therapy. We studied a polymer-free and carrier-free drug-coated stent that transfers umirolimus (also known as biolimus A9), a highly lipophilic sirolimus analogue, into the vessel wall over a period of 1 month.
DOI: 10.1056/NEJMoa1503943
PubMed: 26466021
Affiliations:
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Le document en format XML
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MonashHeart and Monash University, Melbourne, VIC, Australia (I.T.M.); Instituto Dante Pazzanese de Cardiologia, São Paulo (A.A.); London School of Hygiene and Tropical Medicine, London (S.J.P., J.G.), the Dorset Heart Centre Royal Bournemouth Hospital, Bournemouth (S.T.), and West of Scotland Regional Heart and Lung Centre Golden Jubilee National Hospital, Glasgow (K.O.) - all in the United Kingdom; Toulouse Rangueil Hospital, Toulouse (D.C.), Pôle Santé République, Clermont-Ferrand (J.L.), Clinique de la Fontaine, Dijon (P.B.), Hôpital Claude Galien, Institut Cardiovasculaire Paris Sud (ICPS), Générale de Santé, Quincy-sous-Sénart (P.G.), Clinique Saint Hilaire, Rouen (J.B.), Groupe Hospitalier Mutualiste de Grenoble, Grenoble (M.A.), and ICPS, Générale de Santé, Massy (M.-C.M.) - all in France; Contilia Heart and Vascular Center, Elisabeth Krankenhaus, Essen (C.N.), and Herzzentrum Segeberger Kliniken, Bad Segeberg (G.R.) - both in Germany; Complejo Hospital Meixoeiro, Vigo, (A.I.), and Arrixaca University Hospital, Murcia (M.V.-C.) - both in Spain; and the Institute Jantung Negara, Kuala Lumpur, Malaysia (R.Z.).</nlm:affiliation><wicri:noCountry code="subField">Malaysia (R.Z.).</wicri:noCountry></affiliation></author><author><name sortKey="Meredith, Ian T" sort="Meredith, Ian T" uniqKey="Meredith I" first="Ian T" last="Meredith">Ian T. Meredith</name></author><author><name sortKey="Abizaid, Alexandre" sort="Abizaid, Alexandre" uniqKey="Abizaid A" first="Alexandre" last="Abizaid">Alexandre Abizaid</name></author><author><name sortKey="Pocock, Stuart J" sort="Pocock, Stuart J" uniqKey="Pocock S" first="Stuart J" last="Pocock">Stuart J. Pocock</name></author><author><name sortKey="Carrie, Didier" sort="Carrie, Didier" uniqKey="Carrie D" first="Didier" last="Carrié">Didier Carrié</name></author><author><name sortKey="Naber, Christoph" sort="Naber, Christoph" uniqKey="Naber C" first="Christoph" last="Naber">Christoph Naber</name></author><author><name sortKey="Lipiecki, Janusz" sort="Lipiecki, Janusz" uniqKey="Lipiecki J" first="Janusz" last="Lipiecki">Janusz Lipiecki</name></author><author><name sortKey="Richardt, Gert" sort="Richardt, Gert" uniqKey="Richardt G" first="Gert" last="Richardt">Gert Richardt</name></author><author><name sortKey="I Iguez, Andres" sort="I Iguez, Andres" uniqKey="I Iguez A" first="Andres" last="I Iguez">Andres I Iguez</name></author><author><name sortKey="Brunel, Philippe" sort="Brunel, Philippe" uniqKey="Brunel P" first="Philippe" last="Brunel">Philippe Brunel</name></author><author><name sortKey="Valdes Chavarri, Mariano" sort="Valdes Chavarri, Mariano" uniqKey="Valdes Chavarri M" first="Mariano" last="Valdes-Chavarri">Mariano Valdes-Chavarri</name></author><author><name sortKey="Garot, Philippe" sort="Garot, Philippe" uniqKey="Garot P" first="Philippe" last="Garot">Philippe Garot</name></author><author><name sortKey="Talwar, Suneel" sort="Talwar, Suneel" uniqKey="Talwar S" first="Suneel" last="Talwar">Suneel Talwar</name></author><author><name sortKey="Berland, Jacques" sort="Berland, Jacques" uniqKey="Berland J" first="Jacques" last="Berland">Jacques Berland</name></author><author><name sortKey="Abdellaoui, Mohamed" sort="Abdellaoui, Mohamed" uniqKey="Abdellaoui M" first="Mohamed" last="Abdellaoui">Mohamed Abdellaoui</name></author><author><name sortKey="Eberli, Franz" sort="Eberli, Franz" uniqKey="Eberli F" first="Franz" last="Eberli">Franz Eberli</name></author><author><name sortKey="Oldroyd, Keith" sort="Oldroyd, Keith" uniqKey="Oldroyd K" first="Keith" last="Oldroyd">Keith Oldroyd</name></author><author><name sortKey="Zambahari, Robaayah" sort="Zambahari, Robaayah" uniqKey="Zambahari R" first="Robaayah" last="Zambahari">Robaayah Zambahari</name></author><author><name sortKey="Gregson, John" sort="Gregson, John" uniqKey="Gregson J" first="John" last="Gregson">John Gregson</name></author><author><name sortKey="Greene, Samantha" sort="Greene, Samantha" uniqKey="Greene S" first="Samantha" last="Greene">Samantha Greene</name></author><author><name sortKey="Stoll, Hans Peter" sort="Stoll, Hans Peter" uniqKey="Stoll H" first="Hans-Peter" last="Stoll">Hans-Peter Stoll</name></author><author><name sortKey="Morice, Marie Claude" sort="Morice, Marie Claude" uniqKey="Morice M" first="Marie-Claude" last="Morice">Marie-Claude Morice</name></author></analytic><series><title level="j">The New England journal of medicine</title><idno type="eISSN">1533-4406</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Combined Modality Therapy</term><term>Coronary Artery Disease (drug therapy)</term><term>Coronary Artery Disease (therapy)</term><term>Double-Blind Method</term><term>Drug-Eluting Stents (adverse effects)</term><term>Female</term><term>Humans</term><term>Immunosuppressive Agents (administration & dosage)</term><term>Kaplan-Meier Estimate</term><term>Male</term><term>Middle Aged</term><term>Percutaneous Coronary Intervention</term><term>Platelet Aggregation Inhibitors (therapeutic use)</term><term>Polymers</term><term>Prosthesis Design</term><term>Sirolimus (administration & dosage)</term><term>Sirolimus (analogs & derivatives)</term><term>Stents (adverse effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Antiagrégants plaquettaires (usage thérapeutique)</term><term>Association thérapeutique</term><term>Conception de prothèse</term><term>Endoprothèses (effets indésirables)</term><term>Endoprothèses à élution de substances (effets indésirables)</term><term>Estimation de Kaplan-Meier</term><term>Femelle</term><term>Humains</term><term>Immunosuppresseurs (administration et posologie)</term><term>Intervention coronarienne percutanée</term><term>Maladie des artères coronaires ()</term><term>Maladie des artères coronaires (traitement médicamenteux)</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Polymères</term><term>Sirolimus (administration et posologie)</term><term>Sirolimus (analogues et dérivés)</term><term>Sujet âgé</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Immunosuppressive Agents</term><term>Sirolimus</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Immunosuppresseurs</term><term>Sirolimus</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Drug-Eluting Stents</term><term>Stents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Sirolimus</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Sirolimus</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronary Artery Disease</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Endoprothèses</term><term>Endoprothèses à élution de substances</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Platelet Aggregation Inhibitors</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Coronary Artery Disease</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Maladie des artères coronaires</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiagrégants plaquettaires</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Combined Modality Therapy</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Kaplan-Meier Estimate</term><term>Male</term><term>Middle Aged</term><term>Percutaneous Coronary Intervention</term><term>Polymers</term><term>Prosthesis Design</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Association thérapeutique</term><term>Conception de prothèse</term><term>Estimation de Kaplan-Meier</term><term>Femelle</term><term>Humains</term><term>Intervention coronarienne percutanée</term><term>Maladie des artères coronaires</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Polymères</term><term>Sujet âgé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Patients at high risk for bleeding who undergo percutaneous coronary intervention (PCI) often receive bare-metal stents followed by 1 month of dual antiplatelet therapy. We studied a polymer-free and carrier-free drug-coated stent that transfers umirolimus (also known as biolimus A9), a highly lipophilic sirolimus analogue, into the vessel wall over a period of 1 month.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Abdellaoui, Mohamed" sort="Abdellaoui, Mohamed" uniqKey="Abdellaoui M" first="Mohamed" last="Abdellaoui">Mohamed Abdellaoui</name><name sortKey="Abizaid, Alexandre" sort="Abizaid, Alexandre" uniqKey="Abizaid A" first="Alexandre" last="Abizaid">Alexandre Abizaid</name><name sortKey="Berland, Jacques" sort="Berland, Jacques" uniqKey="Berland J" first="Jacques" last="Berland">Jacques Berland</name><name sortKey="Brunel, Philippe" sort="Brunel, Philippe" uniqKey="Brunel P" first="Philippe" last="Brunel">Philippe Brunel</name><name sortKey="Carrie, Didier" sort="Carrie, Didier" uniqKey="Carrie D" first="Didier" last="Carrié">Didier Carrié</name><name sortKey="Eberli, Franz" sort="Eberli, Franz" uniqKey="Eberli F" first="Franz" last="Eberli">Franz Eberli</name><name sortKey="Garot, Philippe" sort="Garot, Philippe" uniqKey="Garot P" first="Philippe" last="Garot">Philippe Garot</name><name sortKey="Greene, Samantha" sort="Greene, Samantha" uniqKey="Greene S" first="Samantha" last="Greene">Samantha Greene</name><name sortKey="Gregson, John" sort="Gregson, John" uniqKey="Gregson J" first="John" last="Gregson">John Gregson</name><name sortKey="I Iguez, Andres" sort="I Iguez, Andres" uniqKey="I Iguez A" first="Andres" last="I Iguez">Andres I Iguez</name><name sortKey="Lipiecki, Janusz" sort="Lipiecki, Janusz" uniqKey="Lipiecki J" first="Janusz" last="Lipiecki">Janusz Lipiecki</name><name sortKey="Meredith, Ian T" sort="Meredith, Ian T" uniqKey="Meredith I" first="Ian T" last="Meredith">Ian T. Meredith</name><name sortKey="Morice, Marie Claude" sort="Morice, Marie Claude" uniqKey="Morice M" first="Marie-Claude" last="Morice">Marie-Claude Morice</name><name sortKey="Naber, Christoph" sort="Naber, Christoph" uniqKey="Naber C" first="Christoph" last="Naber">Christoph Naber</name><name sortKey="Oldroyd, Keith" sort="Oldroyd, Keith" uniqKey="Oldroyd K" first="Keith" last="Oldroyd">Keith Oldroyd</name><name sortKey="Pocock, Stuart J" sort="Pocock, Stuart J" uniqKey="Pocock S" first="Stuart J" last="Pocock">Stuart J. Pocock</name><name sortKey="Richardt, Gert" sort="Richardt, Gert" uniqKey="Richardt G" first="Gert" last="Richardt">Gert Richardt</name><name sortKey="Stoll, Hans Peter" sort="Stoll, Hans Peter" uniqKey="Stoll H" first="Hans-Peter" last="Stoll">Hans-Peter Stoll</name><name sortKey="Talwar, Suneel" sort="Talwar, Suneel" uniqKey="Talwar S" first="Suneel" last="Talwar">Suneel Talwar</name><name sortKey="Urban, Philip" sort="Urban, Philip" uniqKey="Urban P" first="Philip" last="Urban">Philip Urban</name><name sortKey="Valdes Chavarri, Mariano" sort="Valdes Chavarri, Mariano" uniqKey="Valdes Chavarri M" first="Mariano" last="Valdes-Chavarri">Mariano Valdes-Chavarri</name><name sortKey="Zambahari, Robaayah" sort="Zambahari, Robaayah" uniqKey="Zambahari R" first="Robaayah" last="Zambahari">Robaayah Zambahari</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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